《以撒的结合 重生(The Binding of Isaac – Rebirth)》是Nicalis在多平台推出的《以撒的结合》动作游戏的新资料片本作，游戏加入了更加丰富的内容，包括新角色、支持4人合作联机，还有新模式、道具、boss等。 When Isaac’s mother starts hearing the voice of God demanding a sacrifice be made to prove her faith, Isaac escapes into the basement facing droves of deranged enemies, lost brothers and sisters, his fears, and eventually his mother.

The Binding of Isaac is a randomly generated action RPG shooter with heavy Rogue-like elements. Following Isaac on his journey players will find bizarre treasures that change Isaac’s form giving him super human abilities and enabling him to fight off droves o